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The GSSG/GSH ratio in the ALS group was also significantly higher than that in the HC group at the second visit (2.84 vs 1.33, P = 0.0120)

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In vertebrates, unconjugated pterins (tetrahydrobiopterin and molybdopterin) act as cofactors of lipid oxidase, nitric oxide synthase, sulfite and aldehyde oxidases, xanthine dehydrogenase, and in aromatic amino acids hydroxylation and serotonin cascade [6]

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