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While symptoms can be episodic, the ongoing irritation, inflammation, and back pressure from the mechanical obstructions can result in cumulative, irreversible damage to the meibomian glands, the eyelids, and the surface of the eyes

In case of mutations affecting the function of the bile salt transporter, but especially when the FGF19-driven negative feedback pathway is defective, this leads to bile acid diarrhea type 2 (168)
