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also, oxidative stress produces structural changes of cell membranes with decreased adhesion, and the migration of altered tumor cells in neighboring tissues or in distant blood and lymph (Forni et al., 2019)

Chondrocyte apoptosis is a typical characteristic of OA

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To address these challenges, considerable effort has been devoted to the development of advanced delivery systems

These highly unstable molecules are natural byproducts of cellular metabolism, but when left unchecked, they can cause severe oxidative damage to cellular membranes, proteins, and DNA

In addition, eprenetapopt decreased the amount of intracellular GSH and increased the intracellular amount of reactive oxygen species (ROS), followed by induction of apoptosis