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Psychiatry 167 436443

It's one of the first questions patients ask their providers, and honestly, it's the right question to ask

Rashid, H.-M

We also determined that the hydrophobic leucine residues in 1907 (L142, L145, L148, L149, and L152) are buried deeper into the FAT domains leucine binding pocket, up to 1.64 closer than seen in the LD2 model, which was an unexpected finding and may explain the increased affinity of 1907

Treatment with potent copper ionophores (elesclomol, disulfiram, NSC319726) via pulsed exposure for 2 h resulted in an approximately 5- to 10-fold increase in intracellular copper levels, while zinc levels remained unaltered (Figure 6C)

When that happens, damage builds