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Rushing increases leads to more severe gastrointestinal side effects like nausea, constipation, and diarrhea
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In Phase 2, monotherapy at 4.5 mg/week reached 10.8% at 26 weeks

Immediate receptor binding (seconds to minutes), intracellular signaling cascade propagation (minutes to hours), gene expression changes (hours to days), protein synthesis and accumulation (days to weeks), cellular and tissue-level effects (weeks to months)
