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Long-term aerobic glycolysis can uncouple enzymes of normal OXPHOS, causing a chronic Warburg effect and accumulation of intracellular fatty acids, nucleotides, amino acids, and, through the activation of the polyol-mechanism, sorbitol and sorbitol-attracted water (Singh et al., 2021

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Emerging evidence indicates that curcumin attenuates renal fibrosis through Wnt/-catenin (Ho et al., 2016), HO-1 (Zhang et al., 2015) and Nrf2-Keap1 (Soetikno et al., 2013) signaling pathways
