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Before the production of AMPK, its cellular actions inhibit the folate cycle along with de novo purine biosynthesis

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Hypoxia induced switching of the expression of ROR1 and ROR2 through non-canonical WNT5A signaling, resulting in an invasive phenotype of melanoma with reduced sensitivity to BRAF inhibitors (71, 72)

excess cholesterol can be esterified into CE by SOAT and stored within LDs [282,284]

Deleterious TP53 mutations, which are associated with tolerance of aneuploidy 45 , were acquired early in four patients (Fig

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