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NNMT inhibitor caused weight loss and reduced adipose tissue mass in DIO mice Since in vitro studies showed 5-amino-1MQ to have high cell permeability, enzyme selectivity, and cell culture efficacy, a sub-chronic (11-day) proof-of-concept in vivo study was conducted to test the effect of NNMT inhibition on obesity in HFD fed mice

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Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase

] 5-Amino-1MQ (5-amino-1-methylquinolinium) has gained significant attention in metabolic research and clinical applications