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This data can be found here: accession number PRJNA1306780

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91 , 94 , 95 The accelerated destruction of red cells imposes a bilirubin load on an already damaged liver, resulting in an exaggerated increase in serum bilirubin level

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Febuxostat is approved by the FDA to start at 40mg daily, and if the uric acid has not reached goal (less than 6.0mg/dL) after two weeks of treatment the dose can be increased to 80mg daily

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Conversely, the ferroptosis inhibitor Fer-1 and the sodiumglucose cotransporter 2 (SGLT2) inhibitor dapagliflozin can suppress overactivation of the HIF1-/HO1 axis [130, 131]

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Theranostics 12 , 75097531 (2022)

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Chen YH, Wu R, Geng B, et al

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