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MicroRNAs are non-coding RNA molecules (they dont code for a protein) that can alter the regulation of protein expression and function

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Disruption of this balance due to abnormal Keap1 activity, genetic mutations, persistent oxidative or inflammatory stress, or mitochondrial dysfunction weakens ARE-dependent defenses, leading to excessive ROS buildup, lipid peroxidation, protein carbonylation, DNA strand breaks, and compromised detoxification capacity

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