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The prevalence of glaucoma is increasing in aging populations and has reached ~5% in people aged 4080 years 2

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Sirtuin deacetylases, also known as class III KDACs, are localized in various cellular compartments, including the nucleus (SIRT1 and SIRT6), nucleolus (SIRT7), cytoplasm (SIRT2), and mitochondria (SIRT3, SIRT4, and SIRT5) [61]

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