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Macrophage 12 (S)-HETE enhances angiotensin IIinduced contraction by a BLT2 (Leukotriene B4 Type-2 Receptor) and TP (Thromboxane receptor)-mediated mechanism in murine arteries

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Melasma is a form of hyperpigmentation that should never be treated with a laser resurfacing device, as the heat from the laser can actually further entrench the pigment into deeper layers of the skin

When stiffness is severe, it resembles a statue or a freezing-like appearance