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In a large retrospective analysis of 219 patients newly diagnosed with pathological hyperprolactinemia, Colao et al

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doi: 10.3390/cells11111732

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This dose-dependent logic illustrates a fundamental dichotomy: diffusible, low-flux non-radical signals promote adaptation and growth, while excessive non-radical ROS flux acts as a potent inducer of growth arrest and programmed cell death

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