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Treatment of cells with the GPX4 inhibitor RSL3 or the lipophilic oxidant cumene hydroperoxide (CHP) increased endogenous S 0 levels (Fig

The metabolic enzyme methionine adenosyltransferase 2 alpha (MAT2A) is a key regulator of cellular metabolism and is primarily responsible for catalyzing the conversion of L-methionine and adenosine triphosphate (ATP) into S-adenosylmethionine (SAM) 8