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10.1016/S0021-9258(19)45675-5 22 CornierM.-A.DabeleaD.HernandezT
The New England journal of medicine, 350(20), 20422049
The dose of vitamin B12 used in the VISP and NORVIT trials and issues with the design of the VISP trial might have obscured a small but still meaningful benefit to vitamin B12 supplementation (234)
The shot itself is super quick and efficient, taking less than 30 seconds
For active B12 deficiency, most clinicians recommend weekly or biweekly shots for the first 4 to 6 weeks, then a maintenance shot every 1 to 3 months
Supplementing with vitamin B12 lowers homocysteine levels and may improve mood, particularly in response to stress
