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MMPs (such as MMP-1, -2, -3, -7, -9, -13, 14, and ADAMTS-4) are upregulated in IDD and correlate with the severity of degeneration (Huang YC

This eliminates math errors that are especially consequential at the starting dose level

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Between 70 to 88% of patients survive for 25 years following the onset of clinical symptoms, indicating a median time from symptom initiation to death ranging from 24 years to over 45 years

doi: 10.1158/0008-5472.CAN-12-3963 256 ConleySJGheordunescuEKakaralaPNewmanBKorkayaHHeathANet al

Critically, animal studies show no evidence of hallucinations, dependence, or tolerance development with PE-22-28 administration