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Inhibition of Vascularization/Endothelial Cells Increased dermal vascularity (neovascularization/capillary hyperplasia) is implicated in melasma, PIH, and AL [30, 154, 160, 171]

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For instance, TB-500 sulfoxide, which is produced by monocytes when exposed to glucocorticoids, has been shown to inhibit neutrophil chemotaxis and possess strong anti-inflammatory properties [8]