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Washington University and SK Biosciences took a similar approach, genetically fusing SARS-CoV-2 RBD on the exterior surface of the two-component protein nanoparticle I53-50, which is a computationally designed 120-subunit complex with icosahedral symmetry constructed from trimeric (I53-50A) and pentameric (I53-50B) components

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GFP-expressing cells were sorted and clonally diluted in 96-well plates

doi: 10.4088/JCP.10r05993 [DOI] [PMC free article] [PubMed] [Google Scholar] 128

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