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NNMT inhibitors display high membrane permeability Compounds spanning ~100-fold IC 50 values for NNMT inhibition were selected on the basis of positional substitutions around the N-methylated quinolinium scaffold[17] to obtain an estimate of drug-like oral absorption/bioavailability properties and guide the choice of inhibitors for in vitro and in vivo phenotypic studies

Additionally, dyslipidemia, hypertension, and other factors are recognized as potential drivers of MetS pathogenesis (Tilg et al., 2020)

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The latter more closely mimics a medication schedule and may be easier to maintain consistently

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