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The neurological complications of Menkes disease are due not only to loss of important copper-dependent enzymes, such as dopamine -hydroxylase, but also to loss of iron efflux from the brain, as a result of the loss of ceruloplasmin function

However, this process is not instant

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Meanwhile, the body temperature of mice from different groups did not vary significantly from each other, and weekly food consumption displays a large fluctuation between groups, but the trend is consistent between groups (Figures 3C,D)

At the same time, it was found that the number of eosinophils in the blood and the level of ECP in the serum of the AR-HRS group both decreased