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Genes were considered of interest if their Manhattan plot peaks met the following criteria: 1) the peak is above a horizontal line representing a threshold of P = 0.05 with Bonferroni correction, and 2) the peak is at least 3 logs higher than the second highest peak in the pedigree

Although this increase is generally considered safe by the FDA and resolves after cessation of treatment, it is still a potential consideration for patient adherence and preference (82)

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