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Ectopic firing of central neurons triggers and sustains central sensitization, leading to the amplification and perpetuation of pain signals, and the persistence of chronic pain

PengPYuHXingCTaoBLiCHuangJet al

GAT1 also clears GABA from the extracellular space

Endoperoxides The 18 O 2 -labeling evidence by Samuelsson for an endoperoxide intermediate in prostaglandin biosynthesis 351 and the subsequent isolation of PGG 2 and PGH 2 352 sparked great interest in the occurrence of fatty acid endoperoxides and the mechanisms of their formation

In another study, DNA fragmentation and base damage was induced by curcumin in concurrent presence of Cu and isozymes of cytochrome p450 (CYP) present in lung, lymph, liver and skin [421]

Cell 159:514529
