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However, this becomes dysfunctional in AD, further worsening the effects of oxidative stress (Dringen and Arend, 2025)

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doi:10.2147/IJGM.S301900 [PubMed] 126

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Additionally, treatment of DIO mice with the NNMT inhibitor resulted in a substantial ~35% decrease ( P 30% decrease in adipocyte size ( P 40% decrease in adipocyte volume (data not shown) compared to control DIO mice