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Ubidecarenone decreases cell viability in patient-derived organoids and promotes substrate-specific ROS production Due to limitations of cultured cell lines in vitro and cell line-derived xenograft models in vivo as an adequate representation of human disease pathophysiology, the effects of ubidecarenone was assessed in a primary ex vivo model using patient-derived pancreatic tumour organoids (PDO) 20

Progression of the disease can result in micronodular cirrhosis

EGPA is a serious, but treatable disease

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Participants were never smokers, or had smoked less than 5 pack-years, with no smoking in the last year