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Copper is involved in melanin synthesis (hair pigmentation) and is a cofactor for enzymes involved in keratin cross-linking

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By comparing the gene expression profiles of the skin microbiota in acne patients with the profiles from healthy individuals, the vitamin B 12 biosynthesis pathway in the skin bacterium Propionibacterium acnes turned out to be significantly down-regulated in acne patients

Because the IOMs RDA is considerably lower than the EFSAs AI, we chose to provide a lower recommendation to meet the RDA and a higher recommendation to meet the EFSAs AI

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