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By Karin Elgar Abstract Abstract Vitamin B12 (B12) is an essential cofactor in cellular metabolism adequate supplies are needed for normal blood formation and neurological function, and deficiency can therefore lead to macrocytic anaemia and neurological deficits

In an eight-week, randomized, placebo-controlled trial that included 46 menopausal women being treated with citalopram (Celexa), the addition of vitex (equivalent of 1,000 mg dried vitex berry daily) plus black cumin ( Nigella sativa , 500 mg ground seeds daily) to treatment resulted in greater improvements in hot flashes and physical and psychosocial functioning compared with placebo

The bone marrow cannot access it for hemoglobin production

Monitoring Intake People with conditions that affect B12 absorption, such as pernicious anemia or gastrointestinal issues like Crohn's disease, should work with a healthcare provider to regularly monitor their B12 levels and adjust intake as needed

These are considered two of the bioactive forms of B12, and they work well for many

But why do these effects occur