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Description
Higher concentrations (0.1% or above) risk copper overload on compromised skin, which can trigger the copper uglies: persistent redness, breakouts, and worsening sensitivity

doi: 10.1093/mp/ssp002

Phase III trials are large-scale studies to confirm efficacy and fully evaluate the risk-benefit profile

Journal of Immunology
Kahl A, Stepanova A, Konrad C, et al

This reduction causes lower energy, a slower metabolism, and less skin elasticity
