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The result showed an unexpected early death of mature OLs and response of OL progenitor cells (OPCs) in vivo upon CPZ challenge, and a prolonged upregulation of myelin-forming OLs compared to the intact control even 4 weeks after CPZ withdrawal

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Moreover, this rescue did not depend on intracellular re-synthesis of GSH, as pharmacological inhibition of GSH synthesis did not prevent GSH rescue in cystine-free conditions (Extended Data Fig

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