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doi: 10.3109/10715762.2013.807508 115 PutaalaHNurminenPTiihonenK

To date, the mechanisms involved in certain etiologies of liver fibrosis remain to be revealed

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JAMA 2014;311:806814

The latter has been shown to activate adrenergic receptors on platelets, leading to platelet hyperactivation and AS, resulting in narrowing of blood vessels and increased resistance to blood flow [207].Twelve weeks of running-wheel exercise increased plasma BA and fecal BA secretion in mice [208].BA is able to activate cell membrane receptor TGR5, which through cAMP signaling inhibits the transcriptional activity of NF-kB and reduces oxidized low-density lipoprotein load and foam cell formation, which leads to a reduction in pro-inflammatory cytokine production, inhibition of AS, and improvement of vascular wall lesions [209]

Its a hormone thats naturally produced during pregnancy, but dont worry, its not just for expectant moms