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In breast and colorectal cancer cells, NRF2 silencing increased miR-181c-5p expression levels, subsequently suppressing mitochondrial respiration and O 2 consumption by targeting the complex IV subunit, ultimately preventing HIF-1 accumulation under 24-h hypoxic conditions (Fig
This clinical dilemma provides strong indirect support for the E-P-OS network framework
Shabalala SC, Dludla PV, Mabasa L, Kappo AP, Basson AK, Pheiffer C, et al
Escalating the dose to chase a faster result is explicitly not the studied approach
