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Adequate B12 status is necessary for normal cellular function, but supraphysiological dosesbeyond correcting deficiencydo not demonstrably enhance metabolism in individuals with normal B12 levels

One common phenomenon that occurs as a result of an imbalance between the production and accumulation of reactive oxygen species (ROS) in cells and tissues and the bodys antioxidant defense mechanisms is oxidative stress

Nrf2 activators, such as sulforaphane, have shown potential in preventing cataract formation in human lens epithelial cells under oxidative stress conditions

doi: 10.1016/j.amjmed.2010.12.027