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doi: 10.1038/s41572-018-0014-7

The relatively fast absorption and clearance of nasal peptides means multiple smaller doses can maintain more consistent blood levels than a single large dose

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Targeting Tim-3, a checkpoint upregulated in PD-1-resistant patients, also holds promise for restoring T-cell function and reversing adaptive resistance [343]

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doi: 10.1007/s00018-017-2615-9
