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This is a different approach and the early outcomes being studied are strong enough to make experts curious about whether the triple mechanism can translate into meaningful real-world benefits once larger trials confirm safety and long-term results

Other dermatologic adverse reactions reported with oral tretinoin include rash (unspecified) (54%), pruritus (20%), alopecia (14%), unspecified skin changes (14%), cellulitis (8%), facial edema (6%), and pallor (6%)

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Twice daily dosing has been shown to provide superior IOP reduction compared with either agent alone and is noninferior to concomitant separate therapy