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None of the patients developed local or distant disease recurrence at a median follow up of 2.7 years.[106] Genomic alterations Low-grade fibromyxoid sarcoma is characterized by a FUS :: CREB3L2 gene translocation and, rarely, alternative gene translocations such as FUS :: CREB3L1 and EWSR1 :: CREB3L1 .[107,108] Prognosis In a review of 33 patients (3 were younger than 18 years) with low-grade fibromyxoid sarcoma, 21 patients developed a local recurrence after intervals of up to 15 years (median, 3.5 years)

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