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Drugs associated with neurexins modulating synaptic plasticity To understanding the potential of neurexin-modulated synaptic plasticity in sustained antidepressant effect, we further summarize the drugs that may be involved in the modulation of synaptic plasticity by neurexins to expand the drug pool and link depression in depth to unlock the potential that these drugs may have in antidepressant or sustained antidepressant effect

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Ferroptotic cell death results in the release of different DAMPs (e.g., high-mobility-group box 1) or lipid peroxidation products (e.g., 4-HNE) (52), which can further activate inflammation and the corresponding oxidative injury

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Mammalian species have been identified to possess seven classes of cytosolic GSTs, namely alpha, mu, pi, sigma, theta, omega, and zeta, based on similarities in amino acid sequences

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