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Using HD mouse and cell models, we demonstrated that TFEB and TFE3 are sequestered in muHTT aggregates, and muHTT proteins associates with LMP triggering the translocation of LGALS3 to the lumen of lysosomes, with a close relation between polyQ size and severity of these events

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Vegane Kapselhlle aus reiner pflanzlicher Cellulose (HPMC), frei von Carrageen und PEG