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With age, SIRT1 levels decline, disrupting the molecular clock in the SCN and thereby impairing both circadian and metabolic homeostasis ( 3.4 Effects of aging and sleep on the glymphatic system and neuron-glial redox coupling in brain health Aging also impairs the glymphatic system, a crucial brain-wide clearance network responsible for removing interstitial waste products, including neurotoxic and ROS-generating protein aggregates such as amyloid-, -synuclein, and neurofibrillary tangles (Rasmussen et al., 2018

doi: 10.1053/j.gastro.2012.02.003

The MRP2 expression vector pcDNA5/FRT-MRP2 was constructed by cloning the ABCC2 gene into the eukaryotic expression vector pcDNA5/FRT (Life Technologies) as described previously 59 with an additional Kozak sequence added at the beginning of the gene

This therapeutic approach is based on a gas treatment that induces the production of ROS/RNS able to specifically target cancer cells

Relationship between fetal weight, placental growth and litter size in mice from mid- to late-gestation

Muscle carnosine loading by beta-alanine supplementation is more pronounced in trained vs