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Figure 1 This schematic illustrates the key molecular mechanisms contributing to dopaminergic neuron degeneration in Parkinsons disease (PD)

These pathways drive ROS accumulation beyond cellular antioxidant capacity, initiating apoptosis through oxidative stress overload

Nigam SK (2018) The SLC22 transporter family: a paradigm for the impact of drug transporters on metabolic pathways, signaling, and disease

1 2 fda.gov "Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system"

doi:10.1556/068.2016.56.2.2 via Gale Academic Onefile

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