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Liu T, Kan XF, Ma C, Chen LL, Cheng TT, Zou ZW, Li Y, Cao FJ, Zhang WJ, Yao J, et al

Humans are constantly exposed to pollutants through air, soil, ingestion of contaminated food and water [347]

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In both AID patients and corresponding animal models, the expansion and accumulation of MDSCs protect host tissues from damage caused by excessive T cell responses by inhibiting T cell activation and immune reactions (102, 119), This further indicates that MDSCs may exert a detrimental impact on immune responses by modulating the functions of CD4 + and CD8 + T cells, thereby contributing to the pathological processes of AIDs

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