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Intestinal I/R can induce remote brain injury characterized by neuroinflammation, blood-brain barrier disruption, and cognitive impairment

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Marino MJ, Williams DL Jr, OBrien JA, Valenti O, McDonald TP, Clements MK, Wang R, DiLella AG, Hess JF, Kinney GG, Conn PJ (2003) Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinsons disease treatment

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While EGFR family members can compensate IGF-IR inhibition and confer resistance to IGF-IR-targeted agents, IGF-IR can confer resistance to EGFR/ErbB2/ErbB3-targeted therapies as well

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