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The underlying meta-level parameters, such as nutritional value, composition, nutritional effects, metabolism, etc., used in determining substantial equivalence are philosophically derived from performance parameters used for medical devices and hardware systems, which may not meet the needs for assessing the equivalence of biological organisms

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Maskarinec G., Ju D., Morimoto Y., Franke A

Piedra-Quintero ZL, Wilson Z, Nava P, Guerau-de-Arellano M

Hubbert, M

Users anecdotally report that natural sources often provide less of a "pump-and-dump" - the typical caffeine crash doesn't seem to happen as much