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Thirdly, and potentially closely related to the glutamatergic hypothesis, is the theory of oxidative stress [8]

Neuroreport 14 , 359362 (2003)

A reproductive subtype of depression: conceptualizing models and moving toward etiology

Hepatotoxicity Related to Anti-tuberculosis Drugs: Mechanisms and Management

However, excessive glutamate accumulation in the synaptic cleft is neurotoxic due to overstimulation of N-methyl-D-aspartate (NMDA) receptors, leading to elevated intracellular calcium, activation of cell death signaling pathways, and ultimately, neuronal necrosis and apoptosis (Shen et al., 2022)

In contrast to the IgM OSE produced by B1 and MZB cells, the role of IgG OSE in atherosclerosis is less clear and may depend on the subtype of IgG