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These findings are consistent with studies showing knockout of AMs impedes bleomycin induced pulmonary fibrosis 47,48 and more recently that IL-18 high -AMs are highly present in human lung disease, particularly in lung fibrosis 26

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Furthermore, cysteinylglycine dipeptidase is the major activity responsible for the hydrolysis of cysteinyl-bis(glycine) and LTD 4 in these membranes (Campbell et al., 1988, Kozak and Tate, 1982, Tate, 1989)

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