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Li L, Pan Q, Han W, Liu Z, Li L, Hu X

Potential clinical and present clinical applications of sodium thiosulfate Sodium thiosulfate (hereafter referred to as STS or thiosulfate) is an endogenous sulfur metabolite [145], which possesses antioxidant [146], anti-inflammatory [94], and antihypertensive properties [147]
Glutathione is well known as an anti-oxidant agent, providing a major line of defense against oxidative and other forms of stress, largely as a cofactor for the glutathione peroxidase and S-transferase enzyme families (7-10)
screened hub genes based on the weighted correlation network analysis (WGCNA) algorithm and identified interconnected transcription factors (TFs) and non-coding RNAs (ncRNAs) using principal component analysis
Disruption of the Keap1-containing ubiquitination complex as an antioxidant therapy

50,51 They may be less responsive to folic acid therapy and may require higher supplemental folate doses
