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These observations have been translated into therapeutic approaches using iron oxide nanoparticles, which substantially increase intracellular labile iron pools and amplify radiation-induced lipid peroxidation by 3.2-fold [165]

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Vitamins are organic compounds required in small quantities for proper bodily functions and are essential for growth, development, and disease prevention

Mitochondrial dysfunction further exacerbates oxidative stress by impairing ATP production and damaging mitochondrial DNA, leading to compromised sperm motility and energy deficits

This phenomenon is particularly significant in tumors with high SLC7A11 expression, suggesting that these two drugs target tumor oxidative stress pathways through different mechanisms [54, 55]