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However, several effectors (for example, CRBN, DCAF11, DCAF16, FBXO22 and tripartite motif-containing protein 21 (TRIM21)) have been overrepresented in reports of small-molecule degraders 23,25,34,36,60,67,94,95,96,97,98,99,100,101 , despite some, like DCAF16, scoring poorly in previous genetic screens 92,93

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Further research, including randomized controlled trials, is needed to evaluate the efficacy of these interventions