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Although both the peptides cause a greater production of growth hormone (GH), ipamorelin binds with growth hormone secretagogue receptors (GHSR) located in the hypothalamus and in peripheral organs, while sermorelin binds with growth hormone-stimulating hormone receptors (GHSHr) located in the hypothalamus only

For this reason, growing attention has been placed on nootropic peptides and compounds that may support brain health and cognitive performance

doi: 10.2478/pjvs-2013-0049

Br J Pharmacol Chemother 31(2):269 Demertzis S, Scherer M, Langer F, Dwenger A, Hausen B, Schafers HJ (2000) Ascorbic acid for amelioration of reperfusion injury in a lung autotransplantation model in sheep