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It is also important for the normal function and development of the brain and the nerve cells

Vitamin B12 (cobalamin) is a water-soluble vitamin essential for numerous physiological processes, including red blood cell formation, neurological function, and DNA synthesis

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Its core pathological feature is excessive accumulation of adipose tissue, accompanied by abnormal proliferation, differentiation, and metabolic dysfunction of adipocytes, which in turn induce a series of complications including insulin resistance, nonalcoholic fatty liver disease, and cardiovascular diseases

The Phase 2b trial (PMID: 23714218) failed to demonstrate significant weight loss compared to placebo over 12 weeks, despite adequate sample size and dosing