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If levels drop too low, symptoms can begin to appear gradually

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In addition, small molecule dicarboxylates in this pathway (e.g., succinate, fumarate, malate) sustain erythropoiesis by the mechanism of stabilization of the Hypoxia Inducible Factor 1alpha upon exposure to hypoxia, which otherwise is degraded following hydroxylation by alpha-ketoglutarate-dependent prolyl hydroxylases [119]

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Experimental data showed that superoxide anion can react with NO to form peroxynitrite (56) which is generated predominantly in mitochondria

Our bodies are highly demanding of vitamins and minerals to function optimally