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In AA, these modifications including DNA methylation, histone modifications, and microRNAs (miRNAs) can regulate the expression of key immune response genes, thereby contributing to disease initiation and progression [131, 132]

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This X-linked genetic condition affects approximately 1 in 4,000 males and requires lifelong coordinated care, but early detection and intervention can dramatically improve developmental outcomes

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Although the exact mechanism behind this synergy remains unclear, it may involve destabilization of the bacterial outer membrane through the depolymerase action 135

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doi: 10.7759/cureus.32726

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